I use to keep a very small amount of system extensions in my Macs, but this may be a complex topic because each hardware/software combination needs his own combination of system extensions and, furthermore some are dependant of others.
Apple Audio Extension by example is needed in MDD but no in Sawtoth. Sound Manager is needed for QuickTime 6, which also need OpenTransport (I think).
I use to start with empty extensions folder and I go adding extensions as hardware and software require it. To keep the things more clean, I use to put most of the shared libs on the folder of the app that uses it (if is possible).
This is what I use to have on the extensions folder:
Network related extensions:
Apple Enet 2.4.5, AppleShare 3.9.4, Open Transport 2.8.3, Open Transport ASLM Modules 2.8.3, Shared Library Manager PPC 2.0.2, Internet Config Extension 2.0.7
USB/FireWire related extensions:
FireWire Enabler 2.8.7, FireWire Support 2.8.7, HID Library 1.5.9, USB Device Extension 1.5.9
QuickTime And Sound Manager related extensions:
Apple Audio Extension 2.4, Sound Manager 3.7.1, QuickTime Extensions, QuickTime 6.0.3, QuickTime Musical Instruments 6.0.2, QuickTime PowerPlug 6.0.3
OpenG related extensions:
OpenGLEngine 1.2.4, OpenGLLibrary 1.2.5, OpenGLMemory 1.2.4, OpenGLRenderer 1.2.4, OpenGLUtility 1.2.4
Video card related extensions:
NVIDIA 2D Acceleration 3.5.2, NVIDIA Drive 3.5.2, NVIDIA DVD Accelerator 3.5.2, NVIDIA Engine 3.5.2, NVIDIA OpenGL 3.5.2, NVIDIA Video Accelerator 3.5.2
Other Extensions:
DrawSprocketLib 1.7.8, InputSprocket Extension 1.7.3, Time Synchronizer 8.3.3, Contextual Menu Extension 1.0.2, Joliet Volume Access 2.1b5,
Text Encoding Converter 1.6, Apple CD/DVD Driver 1.4.8, DVD Region Manager 1.1, CarbonLib 1.6.1, Multiprocessing
Control Panels:
Joliet Control 2.1b5,USB Overdrive 1.4,Appearance 1.1.4,Date & Time 8.3.3, Energy Saver 3.0.5,File Exchange 3.0.5, General Controls 8.0.3, Internet 1.0.3, Keyboard 8.6.2,Memory 8.1.3,Monitors 7.5.6, Numbers7.1,QuickTime Settings 6.0.2, Sound 8.5.8, Startup Disk 9.2.6,TCP/IP 2.5,Text 8.0
As I am a "Cubase only guy" In my system there isn't a lot of DAW related extensions, Rewire is usually in the trash can (I never liked it), OMS is optional in cubase (I never liked it, too) as Cubase can handle the serial ports for MIDI by it self.
Edited to add version numbers as requested by Protools5LEGuy. Control Panels also added.