In my case, first I tried using the latest Python 3.13.9 both from Windows 7 (bad idea due to resource fork loss) and macOS 10.14.6 Mojave, but neither worked: it seems like that version of Python was just too new. I then retried with Python 3.8.10 instead (which I chose thinking it might be more period-appropriate for the script's age) on Mojave, which worked flawlessly.FYI. I use one specific software for programming HAM radios that relies heavily on Python. The consensus there is that one has to use nothing newer than Python 3.10, because later versions have bugs/compatibility problems.
I'm using MacPorts version 3.10.5 on Yosemite.
As to the mouse and sound issues, did you try to zap PRAM, remove battery and also press the CUDA button? Is everything OK after these procedures too?
EDIT. Another question. Does your ROM file have ATI Via driver integrated into it?