Wow, LMK when you get a PCI audio Interface (like 2496) to work via pass-thru, this would finally make a full working DAW a reality; currently all my "Virtual DAWs" do not perform with "real hardware"
Mostly that should work out of the box, maybe if the cards do Bus Mastering or some other funky PCI functions I don't fully understand it would need a few mods, but the cards do not have option ROMs or I2C busses that require firmware( OpenBIOS ) level mods.
Mostly the OS's runtime drivers for Audio cards are going to take care of everything for you.
Had you ever tried to pass a PCI audio card to qemu-system-ppc? It would likely help is a I finally track down the issue with OS 9 freezing on access to the 2nd CPU, but I've got a pretty good idea what the issue is now, just need time to go back over my work and make sure the interrupt-parent is routed through Uni-North and not directly to Mac-io interrupt-controler.