i´ve never seen - but heard about - that "wrong font size" issue, and it is probably quite rare that a monitor setup can cause this.
step 1 is always to make sure that you do not use >25 years old VGA cables with flatscreens.
for icon positions on the desktop only, the "scrambled positions" problem happens more often, mainly from progams which do not properly set back the pevious resolution (games) but also at reboots after system chrashes.
for the icon position issue there are several utilities which let you store and recall the icon positions, at least.