Two more things possibly worth noting:
1) I briefly experimented with partition placement. That is, placing partitions 418,815 MB or smaller before and after partitions larger than 418,815 MB. It *seems* like once you have a partition larger than 418,815 MB, any partitions after that will likely exhibit issues, although my testing was a bit inconsistent in that regard. That said, I didn't spend much time messing around with it; it seems to make the most sense to keep *all* partitions below that size.
2) The issues on partitions larger than 418,815 MB seem to vary depending on the session and the drive. Sometimes I would only get a small blip in one spot, but on another drive or with another session I'd get lots of static and/or audio from another file. That said I have not (yet, anyway; fingers crossed) experienced *any* issues with partitions 418,815 MB or smaller.
PT LE 5.0.1 and 5.1.1 seem to exhibit identical behavior. It would be interesting to know how other versions compare.
Oh, and I just realized I had been testing using AIFF files. I didn't think to test with SDII. Perhaps I'll try that at some point, although likely not any time soon.